Eating Broccoli Could Guard Against Arthritis
Scientists at the University of East Anglia (UEA) are launching a new project to investigate the benefits of broccoli in the fight against osteoarthritis. Initial laboratory research at UEA has found that a compound in broccoli called sulforaphane blocks the enzymes that cause joint destruction in osteoarthritis - the most common form of arthritis.
Scientists at the University of East Anglia (UEA) are beginning a new project to explore the advantages of broccoli in treating osteoarthritis. Initial laboratory work at UEA has shown that a compound called sulforaphane in broccoli blocks the enzymes that cause joint damage in osteoarthritis-the most common type of arthritis.
Broccoli has previously been associated with reduced cancer risk but this is the first major study into its effects on joint health. With funding from both Arthritis Research UK and the Diet and Health Research Industry Club (DRINC), the £650,000 project will explore how sulforaphane may act to slow or prevent the development of osteoarthritis. It will prepare the way for the first patient trials and could lead to safe new ways of preventing and treating this painful disease.
Broccoli was historically linked with decreased risk of cancer but this is the first major study of its effects on general health. With funding from both Arthritis Research UK and the Diet and Health Research Industry Club (DRINC), the £650,000 project will investigate how sulforaphane can work to delay or prevent osteoarthritis from growing. It'll pave the way for the first patient assessments This could contribute to finding new ways to prevent and treat this debilitating disease.
Sulforaphane is a bioactive compound found in cruciferous vegetables, particularly broccoli. Eating broccoli leads to a high level of sulforaphane in the blood, but scientists don't yet know if the sulforaphane gets into joints insufficient amounts to be effective. This is one of the things that the UEA team hopes to discover. Osteoarthritis is the leading cause of disability in the UK where it affects around six million people.
Sulforaphane is a bioactive ingredient found in cruciferous vegetables, particularly broccoli. Eating broccoli in the blood contributes to a high level of sulforaphane, but scientists still don't know whether the sulforaphane gets inadequate quantities into joints to be successful. This is one of the items the UEA team is trying to discover. Osteoarthritis is the leading disability cause in the United Kingdom.
It is a degenerative joint disease which gradually destroys the cartilage in the joints, particularly in the hands, feet, spine, hips and knees of older it people. There is currently no effective treatment other than pain relief or joint replacement.
It is a degenerative joint disease that gradually loses the cartilage in the joints, particularly in the older people's hands, feet, spine, hips and knees. There is actually no other possible treatment than pain relief or replacement of the joints.
Prof lan Clark, of UEA's School of Biological Sciences, who is leading the research said: "The UK has an aging population and developing new strategies for combating age-related diseases such as osteoarthritis is vital –to improve the quality of life for sufferers but also to reduce the economic burden on society."
Prof. Lan Clark, from UEA 's School of Biological Sciences, who leads the study, said: "Great Britain has an ageing population so it is important to develop innovative approaches to tackle age-related diseases such as osteoarthritis – to boost the quality of life for patients but also to reduce the economic burden on society."
As part of the three-year project, the UEA team will also investigate the effects of other dietary compounds on osteoarthritis, including dially disulphide which is found in high amounts in garlic and also appears to slow the destruction of cartilage in laboratory models.
The UEA team will also study the impact of other dietary compounds on osteoarthritis as part of the three-year project, including dially disulphide, which is present in large concentrations of garlic and also appears to delay cartilage degradation in laboratory models.
A concentrated extract of freeze dried broccoli sprouts cut development of bladder tumors in an animal model by more than half, according to a report in the March 1 issue of Cancer Research.
According to a study in the March 1 issue of Cancer Science, a concentrated extract of freeze dried broccoli sprouts the growth of bladder tumors in an animal model by over half.
This finding reinforces human epidemiologic studies that have suggested that eating cruciferous vegetables like broccoli is associated with reduced risk for bladder cancer, according to the study's senior investigator, Yuesheng Zhang, MD, PhD, professor of oncology at Roswell Park Cancer Institute. "Although.this is an animal study. It provides potent evidence that eating vegetables is beneficial in bladder cancer prevention," he said.
According to senior investigator Yuesheng Zhang, MD , PhD, professor of oncology at the Roswell Park Cancer Institute, this result confirms human epidemiological studies that have indicated consuming cruciferous vegetables such as broccoli is correlated with reduced risk for bladder cancer. "Even though.this is an animal test, it provides powerful proof that vegetable eating is beneficial For the prevention of bladder cancer,' he said.
There is strong evidence that the protective action of cruciferous vegetables derives at least in part from isothyiocyanates (ITC), a group of phytochemicals with well-known cancer preventive activities. "The bladder is particularly responsive to this group of natural chemicals." Zhang said. "In our experiments, the broccoli sprout ITCs after oral administration were selectively delivered to the bladder tissues through urinary excretion."
There is good evidence that cruciferous vegetables' protective action is derived at least in part from isothyiocyanates (ITC), a group of phytochemicals with well-known preventive cancer activities. "The bladder is very sensitive to this community of natural chemicals," said Zhang. "In our experiments the broccoli sprout ITCs were administered selectively to the b after oral administration the bladder tissues were selectively distributed via urinary excretion.
Other cruciferous vegetables with ITCs include mature broccoli, cabbage, kale, collard greens and others. Broccoli sprouts have approximately 30 times more ITCs than mature broccoli, and the sprout extract used by the researchers contains approximately 600 times as much.
Many ITC-adult cruciferous vegetables include mature broccoli, cabbage, kale, collard greens and others. Broccoli sprouts have about 30 times more ITCs than mature broccoli, and the researchers' sprout extract contains around 600 times the volume.
Although animals that had the most protection against development of bladder cancer were given high doses of the extract, Zhang said humans at increased risk for this cancer likely do not need to eat huge amounts of broccoli sprouts in order to derive protective benefits. "Epidemiologic studies have shown that dietary ITCs and cruciferous vegetable intake are inversely associated with bladder cancer risk in humans.
While large doses of the extract were provided to animals that had the most protection against development of bladder cancer, Zhang said humans at elevated risk for this cancer probably do not need to consume massive quantities of broccoli sprouts to reap protective benefits. "Epidemiological studies have shown that dietary ITCs and cruciferous consumption of vegetables are inversely related to bladder cancers Harm to guy.
It is possible that ITC doses much lower than those given to the rats in this study may be adequate for bladder cancer prevention," he said. Zhang and his colleagues tested the ability of the concentrate to prevent bladder tumors in five groups of rats.
It is possible that ITC doses much lower than those given to the rats in this study could be sufficient for the prevention of bladder cancer, "he said. Zhang and his colleagues tested the concentrate's ability to prevent bladder tumors in five rat classes.
The first group acted as a control, while the second group was given only the broccoli extract to test for safety. The remaining three groups were given a chemical, N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in drinking water, which induces bladder cancer. Two of these groups were given the broccoli extract in diet, beginning two weeks before the carcinogenic chemical was delivered.
The first group acted as control, while only the broccoli extract was given to the second group to check for health. For drinking water the remaining three groups were given a drug, N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), which causes cancer of the bladder. Two of these groups obtained the broccoli extract in diet, beginning two weeks before delivery of the carcinogenic chemicals.
In the control group and the group given only the extract, no tumors developed, and there was no toxicity from the extract in the rats.
No tumors formed within the control group and group provided only the extract, and there was no toxicity in the rats from the extract.
About 96 percent of animals given only BBN developed an average of almost two tumors each of varying sizes. By comparison, about 74 percent of animals given a low dose of the extract developed cancer, and the number of tumors per rat was 1.39.
Approximately 96 per cent of animals with only BBN developed an average of nearly two tumors of varying sizes. By contrast, approximately 74 per cent of animals with low extract dose developed cancer, and the number of tumors per rat was 1.39.
The group given the high dose of extract had even fewer tumors. About 38 percent of this high-dose group developed cancer, and the average number of tumors per animal was only .46 and, unlike the other animals, the majority were very small in size.
The group had even fewer tumors, despite the high extract dose. Approximately 38 percent of this high-dose population developed cancer, and the total number of tumors per patient was only.46, and the majority were very small in size, unlike the other species.
Scientists at the University of East Anglia (UEA) are beginning a new project to explore the advantages of broccoli in treating osteoarthritis. Initial laboratory work at UEA has shown that a compound called sulforaphane in broccoli blocks the enzymes that cause joint damage in osteoarthritis-the most common type of arthritis.
Broccoli has previously been associated with reduced cancer risk but this is the first major study into its effects on joint health. With funding from both Arthritis Research UK and the Diet and Health Research Industry Club (DRINC), the £650,000 project will explore how sulforaphane may act to slow or prevent the development of osteoarthritis. It will prepare the way for the first patient trials and could lead to safe new ways of preventing and treating this painful disease.
Broccoli was historically linked with decreased risk of cancer but this is the first major study of its effects on general health. With funding from both Arthritis Research UK and the Diet and Health Research Industry Club (DRINC), the £650,000 project will investigate how sulforaphane can work to delay or prevent osteoarthritis from growing. It'll pave the way for the first patient assessments This could contribute to finding new ways to prevent and treat this debilitating disease.
Sulforaphane is a bioactive compound found in cruciferous vegetables, particularly broccoli. Eating broccoli leads to a high level of sulforaphane in the blood, but scientists don't yet know if the sulforaphane gets into joints insufficient amounts to be effective. This is one of the things that the UEA team hopes to discover. Osteoarthritis is the leading cause of disability in the UK where it affects around six million people.
Sulforaphane is a bioactive ingredient found in cruciferous vegetables, particularly broccoli. Eating broccoli in the blood contributes to a high level of sulforaphane, but scientists still don't know whether the sulforaphane gets inadequate quantities into joints to be successful. This is one of the items the UEA team is trying to discover. Osteoarthritis is the leading disability cause in the United Kingdom.
It is a degenerative joint disease which gradually destroys the cartilage in the joints, particularly in the hands, feet, spine, hips and knees of older it people. There is currently no effective treatment other than pain relief or joint replacement.
It is a degenerative joint disease that gradually loses the cartilage in the joints, particularly in the older people's hands, feet, spine, hips and knees. There is actually no other possible treatment than pain relief or replacement of the joints.
Prof lan Clark, of UEA's School of Biological Sciences, who is leading the research said: "The UK has an aging population and developing new strategies for combating age-related diseases such as osteoarthritis is vital –to improve the quality of life for sufferers but also to reduce the economic burden on society."
Prof. Lan Clark, from UEA 's School of Biological Sciences, who leads the study, said: "Great Britain has an ageing population so it is important to develop innovative approaches to tackle age-related diseases such as osteoarthritis – to boost the quality of life for patients but also to reduce the economic burden on society."
As part of the three-year project, the UEA team will also investigate the effects of other dietary compounds on osteoarthritis, including dially disulphide which is found in high amounts in garlic and also appears to slow the destruction of cartilage in laboratory models.
The UEA team will also study the impact of other dietary compounds on osteoarthritis as part of the three-year project, including dially disulphide, which is present in large concentrations of garlic and also appears to delay cartilage degradation in laboratory models.
A concentrated extract of freeze dried broccoli sprouts cut development of bladder tumors in an animal model by more than half, according to a report in the March 1 issue of Cancer Research.
According to a study in the March 1 issue of Cancer Science, a concentrated extract of freeze dried broccoli sprouts the growth of bladder tumors in an animal model by over half.
This finding reinforces human epidemiologic studies that have suggested that eating cruciferous vegetables like broccoli is associated with reduced risk for bladder cancer, according to the study's senior investigator, Yuesheng Zhang, MD, PhD, professor of oncology at Roswell Park Cancer Institute. "Although.this is an animal study. It provides potent evidence that eating vegetables is beneficial in bladder cancer prevention," he said.
According to senior investigator Yuesheng Zhang, MD , PhD, professor of oncology at the Roswell Park Cancer Institute, this result confirms human epidemiological studies that have indicated consuming cruciferous vegetables such as broccoli is correlated with reduced risk for bladder cancer. "Even though.this is an animal test, it provides powerful proof that vegetable eating is beneficial For the prevention of bladder cancer,' he said.
There is strong evidence that the protective action of cruciferous vegetables derives at least in part from isothyiocyanates (ITC), a group of phytochemicals with well-known cancer preventive activities. "The bladder is particularly responsive to this group of natural chemicals." Zhang said. "In our experiments, the broccoli sprout ITCs after oral administration were selectively delivered to the bladder tissues through urinary excretion."
There is good evidence that cruciferous vegetables' protective action is derived at least in part from isothyiocyanates (ITC), a group of phytochemicals with well-known preventive cancer activities. "The bladder is very sensitive to this community of natural chemicals," said Zhang. "In our experiments the broccoli sprout ITCs were administered selectively to the b after oral administration the bladder tissues were selectively distributed via urinary excretion.
Other cruciferous vegetables with ITCs include mature broccoli, cabbage, kale, collard greens and others. Broccoli sprouts have approximately 30 times more ITCs than mature broccoli, and the sprout extract used by the researchers contains approximately 600 times as much.
Many ITC-adult cruciferous vegetables include mature broccoli, cabbage, kale, collard greens and others. Broccoli sprouts have about 30 times more ITCs than mature broccoli, and the researchers' sprout extract contains around 600 times the volume.
Although animals that had the most protection against development of bladder cancer were given high doses of the extract, Zhang said humans at increased risk for this cancer likely do not need to eat huge amounts of broccoli sprouts in order to derive protective benefits. "Epidemiologic studies have shown that dietary ITCs and cruciferous vegetable intake are inversely associated with bladder cancer risk in humans.
While large doses of the extract were provided to animals that had the most protection against development of bladder cancer, Zhang said humans at elevated risk for this cancer probably do not need to consume massive quantities of broccoli sprouts to reap protective benefits. "Epidemiological studies have shown that dietary ITCs and cruciferous consumption of vegetables are inversely related to bladder cancers Harm to guy.
It is possible that ITC doses much lower than those given to the rats in this study may be adequate for bladder cancer prevention," he said. Zhang and his colleagues tested the ability of the concentrate to prevent bladder tumors in five groups of rats.
It is possible that ITC doses much lower than those given to the rats in this study could be sufficient for the prevention of bladder cancer, "he said. Zhang and his colleagues tested the concentrate's ability to prevent bladder tumors in five rat classes.
The first group acted as a control, while the second group was given only the broccoli extract to test for safety. The remaining three groups were given a chemical, N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN) in drinking water, which induces bladder cancer. Two of these groups were given the broccoli extract in diet, beginning two weeks before the carcinogenic chemical was delivered.
The first group acted as control, while only the broccoli extract was given to the second group to check for health. For drinking water the remaining three groups were given a drug, N-butyl-N-(4-hydroxybutyl) nitrosamine (BBN), which causes cancer of the bladder. Two of these groups obtained the broccoli extract in diet, beginning two weeks before delivery of the carcinogenic chemicals.
In the control group and the group given only the extract, no tumors developed, and there was no toxicity from the extract in the rats.
No tumors formed within the control group and group provided only the extract, and there was no toxicity in the rats from the extract.
About 96 percent of animals given only BBN developed an average of almost two tumors each of varying sizes. By comparison, about 74 percent of animals given a low dose of the extract developed cancer, and the number of tumors per rat was 1.39.
Approximately 96 per cent of animals with only BBN developed an average of nearly two tumors of varying sizes. By contrast, approximately 74 per cent of animals with low extract dose developed cancer, and the number of tumors per rat was 1.39.
The group given the high dose of extract had even fewer tumors. About 38 percent of this high-dose group developed cancer, and the average number of tumors per animal was only .46 and, unlike the other animals, the majority were very small in size.
The group had even fewer tumors, despite the high extract dose. Approximately 38 percent of this high-dose population developed cancer, and the total number of tumors per patient was only.46, and the majority were very small in size, unlike the other species.
Comments
Post a Comment